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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Strong CYP3A4 inducers can lower panobinostat stages by ~70% and cause treatment failure.pentobarbital will reduce the level or result of alosetron by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importan